Statistical analysis using Student's paired t-test analyses of patient mean value from 10 patients revealed that the combination ABM/P-15 grafts demonstrated significantly better mean defect fill of 3.4+/-1.7 mm (73.2%) versus a mean defect fill of 0.6 mm (15.8%) for defects treated with DEBR. The European Federation of Periodontology is a federation of 29 member societies for dentists specialising in Periodontics across Europe. It is imperative that research continues in order to better understand the periodontal diseases associated with HIV-infected individuals and design evidence-based therapeutic regimens. Both groups I and II had statistically significantly greater improvement (P < 0.05) in probing pocket depth than control group. These results suggest that the use of the P-15 synthetic cell-binding peptide combined with ABM yields better clinical results than DEBR. After 1 treatment 62% of sites had decreased to less than 5 mm and after two treatments the corresponding number was 67%. Twelve patients with moderate to advanced periodontitis were selected for this study. Therefore, calculus could possibly play a relevant role in the aetiology and pathogenesis of periodontitis. The results of the current study suggest that corticotomy-facilitated orthodontic tooth movement significantly reduces the total time of treatment. Atotal of 62 samples of GCF were collected from diseased sites and from contralateral, matched healthy sites with minimal or no attachment loss. Subgingival plaque samples were taken for microbiological analysis using the 'checkerboard' DNA-DNA hybridisation technique at baseline, immediately after treatment and at 2 and 6 months. A total of 335 patients with periodontal disease (men = 162, women = 173), aged 30 to 79, were randomized to either placebo or ALN 70 mg once weekly. There has been a recent increase in interest in using xenografts and alloplasts. Amoxicillin 3 μg/mL revealed a reduction of 2.4 log 10 CFU, whereas 50% of the samples did not grow on the plates supplemented with 8 μg/mL of amoxicillin. Periodontics. Using primary rat calvarial osteoblastic cells obtained from 21-day old neonatal rats, we determined MMP-13 gene expression when stimulated by parathyroid hormone (PTH), interleukin (IL)-1b, or tumour necrosis factor (TNF)-alpha in the presence or absence of CMT-8 or -5. It was concluded that low Il-1beta levels observed in the young adults group might explain the less pronounced clinical signs observed during the development of gingivitis in the younger subjects. Treatments that aim to reduce the accumulation of bacteria on dental surfaces are considered today as the most efficient way of treating gingivitis and the resultant destruction of periodontal tissues. All individuals were clinically examined and answered a detailed questionnaire. Moreover, the acceleration of tooth movement through the proposed technique motivated patient cooperation. In this study, we studied MMP-13 gene expression and regulation in osteoblasts by chemically modified tetracyclines (CMTs). Several studies have shown that the probability of achieving lasting stability as measured by the arrest of progressive attachment loss and bone loss by primary mechanical therapy is a function, in major part, of whether pathogenic microorganisms are still present at local subgingival sites at the completion of active therapy. There was a high prevalence of chronic inflammatory periodontal disease in this population, and most of this was untreated. journal of periodontology. However, CMT-8 inhibited MMP-13 expression from IL-1b and PTH stimulated cells while having little effect on TNF-alpha stimulated MMP-13 expression. Journal of Periodontology 2005; 76:2033-41. More from this journal Special Issues; SEO Guidelines for Authors; Related Issues Issue Volume 10, Issue 3. Periodontitis is a problem in AA patients. Eighty teeth in 18 patients were evaluated using a split mouth design. Microbial analysis showed a statistically significant greater reduction in the percentages of detection for B. forsythus, P. nigrescens and A. naeslundii genospecies II in pockets where tetracycline fibres were applied. All teeth exhibited excessive mobility. Thus the new technique was considered more suitable for the treatment of gingival recessions with the allograft. The sociodemographic characteristics and periodontal findings were recorded and statistically analyzed. Smokers accounted for 62% of patients, and 71% of the patients had severe periodontal disease. The aim of the present study was to investigate the long-term effect of amine fluoride/stannous fluoride (AmF/SnF2) toothpaste on plaque levels and gingivitis in adults, as an additional measure to standard oral hygiene. The reductions in bleeding scores, although greater than for the chlorhexidine group, were modest. Chediak-Higashi syndrome (CHS) is a rare autosomal recessive genetic disease. Scaling and root-planing treatment with adjunctive subgingival minocycline. A split-mouth experimental design was used. The infecting bacterial species are susceptible to killing by several antibiotics including, among others, tetracycline-class drugs, amoxicillin and metronidazole as well as by local exposure to chlorhexidine. Non-surgical periodontal therapy: mechanical debridement, antimicrobial agents and other modalities, Local delivery of chlorhexidine gluconate in patients with aggressive periodontitis, Phenotypic and Functional Analysis of Peripheral Blood Mononuclear Cells in Generalized Aggressive Periodontitis and Chronic Periodontitis Patients, The use of tetracycline fibres in the treatment of generalised aggressive periodontitis, Apoptotic activity of gingival crevicular fluid from localized aggressive periodontitis, Neutrophil function and periodontitis in alcohol-dependent males without medical disorders, The effect of alendronate sodium on alveolar bone loss in periodontitis, Osseous grafting part II: Xenografts and alloplasts for periodontal regeneration—A literature review, Epidemiologic observations on the clinical crown to root ratio, the root contour, and the alveolar housing of the jaws in white, black and Asian races, Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis, Alveolar ridge preservation using resorbable bioactive ceramic composite: a histological study, instructions how to enable JavaScript in your web browser, Journal of the International Academy of Periodontology website. The duration from disease onset to treatment of thyroid disorders may be critical, since uncontrolled thyroid disease may result in destruction of the periodontium. A similar result was obtained in late-passage human gingival fibroblasts. A. actinomycetemcomitans and P. gingivalis strains differ in genotype, serotype, toxin and enzyme production, and cellular invasiveness. Periodontally-affected teeth were randomly divided into 4 groups of 12 teeth in each. Information for Authors Download PDF Endnote Style for JIAP. Similar results were obtained in smokers, diabetes patients and patients with a history of cardiovascular disease. The orientation and absence of dental plaque was confirmed using light microscopy for each sample prior to inclusion in this study. September 2020. Results indicated that there was increasing gingival inflammation in the right palatal gingiva by day 7, and this became worse by day 21. Both types can be obtained either intraorally or extraorally. At re-examination, subjects judged to need periodontal surgery were treated and re-examined after a further 3 months. The International Academy of Periodontology was established in 1985 to improve knowledge and disseminate information about periodontics worldwide to those who have an interest in the prevention and treatment of diseases of the periodontium by: Advancing international co-operation on a personal basis and in co-operation with national or international periodontal … Malnutrition and poor oral hygiene were associated with the necrotizing process and favored progression from the gingiva to deeper periodontal tissues and other structures within the oral cavity or the facial tissues. The Journal Impact 2019-2020 of Journal of the International Academy of Periodontology is 2.750, which is just updated in 2020.Compared with historical Journal Impact data, the Metric 2019 of Journal of the International Academy of Periodontology grew by 186.46 %.The Journal Impact Quartile of Journal of the International Academy of Periodontology is Q3. However, the metronidazole gel alone or in combination with scaling does not seem to have any additional clinically significant therapeutic effects over and above those derived from improved oral hygiene resulting from monthly recalls, with or without subgingival scaling. The Journal of International Academy of Periodontology. No patients had human immunodeficiency virus (HIV) or AIDS, which makes these findings different from other reports. Therefore, periodontal therapy could influence metabolic control or systemic inflammation leading to diabetic complications. The other half were prepared to assess PDL cell adhesion with PDL fibroblasts being cultured and seeded on the root surface for 24 hours then processed for SEM evaluation of the adherent cells. Journal of Indian Society of Periodontology (JISP) is a peer-reviewed, open-access journal with an aim to convey scientific progress in periodontology and is dedicated to global and extensive publication for the benefit of oral health. Under standardized viewing conditions, the distance from the cementoenamel junction to the interproximal alveolar crest on both the mesial and distal surfaces of each fully erupted permanent tooth present was measured. After instrumentation the percentage of the furcation area with residual artificial calculus was assessed using a computerised imaging system. Periodontal status and cytoplasmic enzyme activities in gingival crevicular fluid of type 2 diabetic and/or obese patients with chronic periodontitis. Although these devices differ with regard to ease of use, concentration of drug delivered and length of time high drug concentrations can be maintained, randomized clinical trials have shown that their use as an adjunctive treatment to scaling and root planing results in a significantly greater reduction of periodontal pocket depth and an average increase in clinical periodontal attachment level of about 0.8 mm. There was no statistically significant increase in the width of keratinized tissue between six and 12 months for either group. The test teeth received SRP and a 25% metronidazole gel applied subgingivally on days 0 and 7. The first one compared the use of the acellular dermal matrix with the subepithelial connective tissue graft and showed 1.83 and 2.10 mm of recession reduction, respectively. All patients completed the trial. A statistically significant greater recession reduction favoring the test procedure was achieved. All patients had at least one tooth in each quadrant with probing pocket depth of > or = 5mm. The combined mechanical/antimicrobial treatment for the chlorhexidine group did not result in any reduction in probing depth and only limited reduction of bleeding scores. The effects of EDTA gel conditioning exposure time on periodontitis-affected human root surfaces: surface topography and PDL cell adhesion. Samples were prepared for transmission electron microscopic (TEM) observation after immunogold staining with polyclonal antibodies for the presence of Actinobacillus actinomycetemcomitans (A. Fifteen adults (13 males, 2 females) with moderate to advanced adult periodontitis were recruited for the study. From the 12-month results, it was concluded that the metronidazole 25% gel produced positive effects on the clinical parameters and on the subgingival plaque microbiological composition in new, residual or recurrent pockets in previously treated chronic periodontitis patients. All these gingival changes reversed to baseline levels during the recovery period by day 42. However, further work by way of a large-scale definitive study is necessary to confirm the results of this investigation. Obesity did not seem to be a significant factor in any parameters evaluated. Spontaneous proliferative response of G-AP and CP groups was also significantly lower compared to that of H group (P < 0.02). After an 8-year period, the previously denuded root surfaces were entirely covered by soft tissue. The LDD-treated group (n = 8 subjects) self administered low dose doxycycline b.i.d. For the older adults group the Il-1beta values increased significantly at day 21 and recovered at day 28. In contrast, CMT-5 only inhibited PTH stimulated MMP-13 expression, with no effect on IL-1b or TNF-alpha stimulated MMP-13 expression. Periodontol.”. Each patient had one or more implants with probing depth > or = 4 mm combined with bleeding and/or exudate on probing and presence of putative pathogenic bacteria. Seven patients with bilateral Miller class I or II gingival recession were selected. The prevalence of periodontal destruction was significantly high, as 91.3% of the participants had at least one tooth with attachment loss > or = 7 mm and 73% presented with mean loss of attachment > 4 mm. A statistically significant difference in bone density (P < 0.001) was observed favouring the alendronate group (Group I). In AA males with excessive alcohol use, neutrophils show depressed NBK. Blood levels of gamma-glutamyl transpeptidase (GGTP) were determined and used as a measure of alcohol consumption. However, there was no significant difference in the blastogenic response to PHA between G-AP and CP groups (P > 0.05). ISSN : 2581-9836. However, limited data are available regarding the relationship between thyroid hormone imbalance (thyroid disease) and periodontal health. Effects on the clinical indices and gingival crevicular fluid enzyme activities of the cyclical regimen of low-dose doxycycline therapy for adult periodontitis, Additive or synergistic antimicrobial effects of amoxicillin and metronidazole on whole plaque samples: a preliminary report. There was a statistically significant difference between the two groups regarding the treatment duration: 17.5 +/- 2.8 weeks in the CFO group and 49 +/- 12.3 weeks in the conventional orthodontic therapy group. A 13-year-old African American male presented with severe gingival inflammation, generalized gingival bleeding, and tooth looseness. The aim of this type of surgery was to maintain an adequate amount of attached gingiva and to prevent continuous loss of attachment. The aim of this study was to examine a potential link between apoptotic biomarkers in gingival crevicular fluid (GCF) and periodontal destruction in four cases of localized aggressive periodontitis (LAP), diagnostically enhanced by cone beam computed tomography. ), Porphyromonas gingivalis (P. g.) and Treponema denticola (T. d.). In skin inflammation and periodontal diseases, fibroblasts may express the IL-8 gene even without an exogenous cytokine, IL-1beta or TNF-alpha, during their proliferation similar to the situation in our culture system. Peri‐implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. The appliance design featured a base plate on the right side which extended to the gingival margin, but which on the left, was relieved from the gingival margin by 6mm. One group of five young subjects (20-22 years old) and another group of five older subjects aged 61-65 years were involved in the study. Thus, the question as to what extent the combined mechanical/minocycline treatment could be considered adequate for the treated lesions remains to be answered. Stay Connected With 70% of the world's HIV-infected population living in sub-Saharan Africa, the economic, social and health care challenges are staggering. Stefan Zimmer, Professor, Department of Operative and Preventive Dentistry and Endodontics, Section of Periodontology, Heinrich-Heine-University, Düsseldorf, Germany. All plates were incubated anaerobically at 36°C for 14 days and the colony forming units (CFU) were determined. Periodontal disease is characterized by periodontal bone loss. Calculus was removed in as large pieces as possible by the use of a sickle or a push scaler placed underneath the apical or facial border of the calculus and fracturing it from the tooth surface in a single stroke. Dentine exposure results from a combination of two or more aetiological factors that lead to loss of enamel and/or loss of cementum. In addition, to assess any correlations between root surface changes following EDTA gel conditioning and periodontal ligament fibroblast adhesion. Journal of Clinical Periodontology … To evaluate the effect of bone grafting in corticotomy-facilitated orthodontics in adults, using a further modified conventional corticotomy technique. Tetracycline fibres were applied in 5 pockets located in the same half mouth. No apparent clinical spillover effect of minocycline was demonstrated over the six months of the study. Teeth in the third group (G3) were conditioned with a pH neutral, 24% Ethylenediaminetetraacetic acid (EDTA gel), for 2 minutes without any scaling or root planing and immediately extracted. The relative counts of CD3+, CD4+, CD8+ T cells, T cells exhibiting HLA DR antigen and interleukin-2 receptor, CD19+ B cells and natural killer cells were determined by two colour flow cytometry using monoclonal antibodies. A single, masked examiner performed clinical assessments. Clinical examination revealed that the upper right central incisor had a recession of 7 mm. Measurements referring to bleeding on probing (BOP), pocket depth (PD) and clinical attachment level (CAL) were performed at 12 sites randomly selected. Subgingival microbiological culture showed the presence of Porphyromonas gingvalis, Prevotella intermedia and Tannerella forsythia. Specifically, several studies have demonstrated the efficacy of minocycline microspheres (Arestin). A clinical pilot study over six months, of sites adjacent to and remote from the antibiotic application. The gingival tissues were swollen and bled easily. 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